Typically, drilling hydraulics optimizations (maximum jet impact and maximum hydraulic horsepower) are based on an assumption of a fixed system. In real operation, you cannot fix flow rate to drill all the way to TD because the system pressure loss is changed because of hole depth, drilling mud properties, wellbore conditions, etc.
There are two ways of optimizing drilling hydraulics which are optimization at the beginning of the run and at the end of the run.
Drilling Hydraulics Optimized at the Beginning of the Run
If the system is designed to meet the maximum hydraulic horsepower at the beginning of the well and the pump pressure is maintained constant at the designed value, when the well is getting deeper, the flow rate must be reduced to maintain the pressure. With this situation, it will cause the jet velocity and hydraulic horsepower dropping (see the curve below) at the end.